Pfam 22.0 :: XPA_N
Description of the XPA_N family
XPA_C <-- --> XPC-binding

XPA_N


Accession number: PF01286
XPA protein N-terminal

Description

Xeroderma pigmentosum (XP) PUBMED:8160271 is a human autosomal recessive disease, characterised by a high incidence of sunlight-induced skin cancer. Skin cells of individuals with this condition are hypersensitive to ultraviolet light, due to defects in the incision step of DNA excision repair. There are a minimum of seven genetic complementation groups involved in this pathway: XP-A to XP-G. XP-A is the most severe form of the disease and is due to defects in a 30 kDa nuclear protein called XPA (or XPAC) PUBMED:1918083. The sequence of the XPA protein is conserved from higher eukaryotes PUBMED:1764072 to yeast (gene RAD14) PUBMED:1741034. XPA is a hydrophilic protein of 247 to 296 amino-acid residues which has a C4-type zinc finger motif in its central section. Xeroderma pigmentosum (XP) PUBMED:8160271 is a human autosomal recessive disease, characterised by a high incidence of sunlight-induced skin cancer. Skin cells of individuals with this condition are hypersensitive to ultraviolet light, due to defects in the incision step of DNA excision repair. There are a minimum of seven genetic complementation groups involved in this pathway: XP-A to XP-G. XP-A is the most severe form of the disease and is due to defects in a 30 kDa nuclear protein called XPA (or XPAC) PUBMED:1918083. The sequence of the XPA protein is conserved from higher eukaryotes PUBMED:1764072 to yeast (gene RAD14) PUBMED:1741034. XPA is a hydrophilic protein of 247 to 296 amino-acid residues which has a C4-type zinc finger motif in its central section.
Description text from InterPro entry IPR000465

Sequence information


Alignment

Seed (6)  Full (26)
Format:

Visualize domain structures

Seed (6)  Full (26)
display per page.

Species distribution

Tree depth:

Database References

PROSITE PDOC00611
SCOP 1xpa (family)
INTERPRO IPR000465

HMMER build information

Pfam_ls [download HMM] Pfam_fs [download HMM]
Gathering cutoff 25.00 25.00 25.00 25.00
Trusted cutoff 25.30 25.30 25.00 37.50
Noise cutoff 23.30 23.30 24.90 24.30
Build method of HMM hmmbuild -F HMM_ls SEED
hmmcalibrate --seed 0 HMM_ls
 hmmbuild -f -F HMM_fs SEED
hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entryFinn RD, Bateman A, Studholme, DJ
Type definitionDomain
Source of seed membersProsite