Pfam 22.0 :: WIF
Description of the WIF family
WI12 <-- --> WLM

WIF


Accession number: PF02019
WIF domain

The WIF domain is found in the RYK tyrosine kinase receptors P34925 and WIF the Wnt-inhibitory- factor. The domain is extracellular and and contains two conserved cysteines that may form a disulphide bridge. This domain is Wnt binding in WIF, and it has been suggested that RYK may also bind to Wnt [1].

Description

The WIF domain is found in the RYK tyrosine kinase receptors and WIF the Wnt-inhibitory-factor. The domain is extracellular and and contains two conserved cysteines that may form a disulphide bridge. This domain is Wnt binding in WIF, and it has been suggested that RYK may also bind to Wnt PUBMED:10637605.
Description text from InterPro entry IPR003306

Sequence information


Alignment

Seed (6)  Full (38)
Format:

Visualize domain structures

Seed (6)  Full (38)
display per page.

Species distribution

Tree depth:

Literature References

[1]
The WIF module.
Patthy L;
Trends Biochem Sci 2000;25:12-13.

Database References

INTERPRO IPR003306

HMMER build information

Pfam_ls [download HMM] Pfam_fs [download HMM]
Gathering cutoff 25.00 25.00 25.00 25.00
Trusted cutoff 29.70 29.70 36.40 36.40
Noise cutoff 13.60 13.60 11.10 11.10
Build method of HMM hmmbuild -F HMM_ls SEED
hmmcalibrate --seed 0 HMM_ls
 hmmbuild -f -F HMM_fs SEED
hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entryBateman A
Type definitionFamily
Source of seed members[1]