Accession number: PF00277
Serum amyloid A protein
|
Description
The serum amyloid A (SAA) proteins comprise a family of vertebrate proteins
that associate predominantly with high density lipoproteins (HDL) PUBMED:7504491, PUBMED:8188253. The
synthesis of certain members of the family is greatly increased (as much as a
1000 fold) in inflammation; thus making SAA a major acute phase reactant.
While the major physiological function of SAA is unclear, prolonged elevation
of plasma SAA levels, as in chronic inflammation, however, results in a
pathological condition, called amyloidosis, which affects the liver, kidney
and spleen and which is characterized by the highly insoluble accumulation of
SAA in these tissues.
SAA are proteins of about 110 amino acid residues. The most highly conserved
region is located in the central part of the sequence.
Description text from InterPro entry IPR000096
|
|
