Pfam 22.0 :: Rad9_Rad53_bind
Description of the Rad9_Rad53_bind family
Rad9 <-- --> RadC

Rad9_Rad53_bind


Accession number: PF08605
Fungal Rad9-like Rad53-binding

In Saccharomyces cerevisiae the Rad9 a key adaptor protein in DNA damage checkpoint pathways. DNA damage induces Rad9 phosphorylation, and Rad53 specifically associates with this region of Rad9, when phosphorylated, via Rad53 PFAM:PF00498 domains [1]. There is no clear higher eukaryote ortholog to Rad9.

Description


Description text from InterPro entry IPR013914

Sequence information


Alignment

Seed (8)  Full (14)
Format:

Visualize domain structures

Seed (8)  Full (14)
display per page.

Species distribution

Tree depth:

Literature References

[1]
The FHA domain is a modular phosphopeptide recognition motif.
Durocher D, Henckel J, Fersht AR, Jackson SP;
Mol Cell. 1999;4:387-394.

Database References

INTERPRO IPR013914

HMMER build information

Pfam_ls [download HMM] Pfam_fs [download HMM]
Gathering cutoff 25.00 25.00 25.00 25.00
Trusted cutoff 45.60 45.60 53.00 53.00
Noise cutoff -43.20 -43.20 12.80 12.80
Build method of HMM hmmbuild -F HMM_ls SEED
hmmcalibrate --seed 0 HMM_ls
 hmmbuild -f -F HMM_fs SEED
hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entryWood V, Finn RD
Type definitionFamily
Source of seed membersManual