Accession number: PF02144
Repair protein Rad1/Rec1/Rad17
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Description
REC1 of Ustilago maydis plays a key role in regulating the genetic system
of the fungus. REC1 mutants are very sensitive to UV light. Mutation
leads to a complex phenotype with alterations in DNA repair, recombination,
mutagenesis, meiosis and cell division PUBMED:8276878. The predicted product of the
REC1 gene is a polypeptide of 522 amino acid residues with molecular mass
57 kD. The protein shows 3'--5' exonuclease activity, but only in cells
over-expressing REC1 PUBMED:8276878. While it is distinguishable from the major
bacterial nucleases, the protein has certain enzymatic features in common
with epsilon, the proof-reading exonuclease subunit of Escherichia coli DNA polymerase
III holoenzyme PUBMED:8276878.
The rad1 gene of Schizosaccharomyces pombe comprises three exons and encodes
a 37 kD protein that exhibits partial similarity to the REC1 gene of
U. maydis PUBMED:7926829. The two genes share putative functional similarities
in their respective organisms.
Description text from InterPro entry IPR003021
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