Pfam 22.0 :: P16-Arc
Description of the P16-Arc family
P120R <-- --> P19Arf_N

P16-Arc


Accession number: PF04699
ARP2/3 complex 16 kDa subunit (p16-Arc)

The Arp2/3 protein complex has been implicated in the control of actin polymerisation. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3, and five others referred to as p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc. The precise function of p16-Arc is currently unknown. Its structure consists of a single domain containing a bundle of seven alpha helices [1,2].

Description

The Arp2/3 protein complex has been implicated in the control of actin polymerization. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3, and five others referred to as p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc. The precise function of p16-Arc is currently unknown. Its structure consists of a single domain containing a bundle of seven alpha helices PUBMED:9230079, PUBMED:11721045.
Description text from InterPro entry IPR006789

Sequence information


Alignment

Seed (10)  Full (80)
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Species distribution

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Literature References

[1]
The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.
Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ;
J Cell Biol 1997;138:375-384.
[2]
Crystal structure of Arp2/3 complex.
Robinson RC, Turbedsky K, Kaiser DA, Marchand JB, Higgs HN, Choe S, Pollard TD;
Science 2001;294:1679-1684.

Database References

INTERPRO IPR006789

HMMER build information

Pfam_ls [download HMM] Pfam_fs [download HMM]
Gathering cutoff 25.00 25.00 25.00 25.00
Trusted cutoff 34.50 34.50 33.30 29.20
Noise cutoff 18.80 18.80 24.00 24.00
Build method of HMM hmmbuild -F HMM_ls SEED
hmmcalibrate --seed 0 HMM_ls
 hmmbuild -f -F HMM_fs SEED
hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entryWaterfield DI, Mifsud W, Finn RD
Type definitionDomain
Source of seed membersPfam-B_4180 (release 7.5)