Pfam 22.0 :: N6_N4_Mtase (KISTI)

Pfam 22.0 :: N6_N4_Mtase
Description of the N6_N4_Mtase family

N6_Mtase <--	--> NA37
N6_N4_Mtase

Accession number: PF01555
DNA methylase

Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.

Description
This domain is found in DNA methylases. In prokaryotes, the major role of DNA methylation is to protect host DNA against degradation by restriction enzymes. This family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases. N-4 cytosine-specific DNA methylases () PUBMED:7607512 are enzymes that specifically methylate the amino group at the C-4 position of cytosines in DNA. Such enzymes are found as components of type II restriction-modification systems in prokaryotes. Such enzymes recognize a specific sequence in DNA and methylate a cytosine in that sequence. By this action they protect DNA from cleavage by type II restriction enzymes that recognize the same sequence. N-6 adenine-specific DNA methylases () (A-Mtase) are enzymes that specifically methylate the amino group at the C-6 position of adenines in DNA. Such enzymes are found in the three existing types of bacterial restriction-modification systems (in type I system the A-Mtase is the product of the hsdM gene, and in type III it is the product of the mod gene). All of these enzymes recognize a specific sequence in DNA and methylate an adenine in that sequence.
Description text from InterPro entry IPR002941

Sequence information

Alignment

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Seed (49) Full (1096)

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Species distribution

Tree depth:

Database References

HOMSTRAD	N6_N4_Mtase
PFAMB The following Pfam-B families contain sequences that according to Prodom are members of this Pfam-A family.	PB020818 PB020911 PB026143 PB108948 PB146530 PB170062 PB171111 PB171435 PB171898 PB174078 PB176515 PB179471 PB179968 PB180005
PROSITE	PDOC00087 PDOC00088
SCOP	1boo (family)
INTERPRO	IPR002941

HMMER build information

	Pfam_ls [download HMM]	Pfam_fs [download HMM]
Gathering cutoff	-36.40 -36.40	13.80 13.80
Trusted cutoff	-36.10 -36.10	13.90 13.90
Noise cutoff	-36.70 -36.70	13.70 13.70
Build method of HMM	hmmbuild -F HMM_ls SEED hmmcalibrate --seed 0 HMM_ls	hmmbuild -f -F HMM_fs SEED hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entry	Bateman A
Type definition	Family
Source of seed members	Pfam-B_164 (release 4.0)