Pfam 22.0 :: Lactamase

Pfam 22.0 :: Lactamase_B
Description of the Lactamase_B family

Lact-deh-memb <--	--> Lactate_perm
Lactamase_B

Accession number: PF00753
Metallo-beta-lactamase superfamily

Description
Apart from the beta-lactamases a number of other proteins contain this domain PUBMED:7588620. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor.
Description text from InterPro entry IPR001279

Sequence information

Alignment

Format:

Visualize domain structures

Seed (315) Full (6656)

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Species distribution

Tree depth:

Literature References

[1]
Extracting protein alignment models from the sequence database.
Neuwald AF, Liu JS, Lipman DJ, Lawrence CE;
Nucleic Acids Res 1997;25:1665-1677.

[2]
The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold.
Carfi A, Pares S, Duee E, Galleni M, Duez C, Frere JM, Dideberg O;
EMBO J 1995;14:4914-4921.

Database References

HOMSTRAD	blmb
PFAMB The following Pfam-B families contain sequences that according to Prodom are members of this Pfam-A family.	PB001049 PB001056 PB001101 PB001106 PB002237 PB002359 PB002484 PB003603 PB004150 PB007744 PB008012 PB008015 PB008528 PB009397 PB009500 PB009597 PB010328 PB010617 PB013187 PB013495 PB014848 PB015166 PB016397 PB016811 PB023025 PB023813 PB025532 PB028756 PB031895 PB035552 PB041762 PB044107 PB045061 PB050554 PB056259 PB058080 PB059168 PB062553 PB065470 PB066689 PB074413 PB075197 PB078733 PB086340 PB087460 PB090869 PB105880 PB108284 PB110240 PB122992 PB123083 PB125306 PB142228 PB153763 PB153767 PB159992 PB169020 PB169484 PB169720 PB170038 PB170516 PB171033 PB171191 PB171345 PB171744 PB172171 PB173344 PB173402 PB173643 PB174708 PB174722 PB176313 PB181262 PB182219 PB182224
SCOP	1bme (family)
INTERPRO	IPR001279

HMMER build information

	Pfam_ls [download HMM]	Pfam_fs [download HMM]
Gathering cutoff	24.60 24.60	20.20 20.20
Trusted cutoff	24.60 24.60	20.20 20.20
Noise cutoff	24.50 24.50	20.10 20.10
Build method of HMM	hmmbuild -F HMM_ls SEED hmmcalibrate --seed 0 HMM_ls	hmmbuild -f -F HMM_fs SEED hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entry	Ponting CP, Bateman A
Type definition	Domain
Source of seed members	[1]