Pfam 22.0 :: LACT
Description of the LACT family
LAB_N <-- --> LAG1

LACT


Accession number: PF02450
Lecithin:cholesterol acyltransferase

Lecithin:cholesterol acyltransferase (LACT) is involved in extracellular metabolism of plasma lipoproteins, including cholesterol.

Description

Lecithin:cholesterol acyltransferase (LACT) also known as phosphatidylcholine-sterol acyltransferase (), is involved in extracellular metabolism of plasma lipoproteins, including cholesterol. It esterifies the free cholesterol transported in plasma lipoproteins, and is activated by apolipoprotein A-I. Defects in LACT cause Norum and Fish eye diseases.
Description text from InterPro entry IPR003386

Sequence information


Alignment

Seed (7)  Full (258)
Format:

Visualize domain structures

Seed (7)  Full (258)
display per page.

Species distribution

Tree depth:

Literature References

[1]
Cloning and in vitro expression of rat lecithin:cholesterol acyltransferase.
Wang J, Gebre AK, Anderson RA, Parks JS;
Biochim Biophys Acta 1997;1346:207-211.

Database References

PFAMB
The following Pfam-B families contain sequences that according to Prodom are members of this Pfam-A family.
PB088988 PB093292 PB158624 PB170153 PB170365 PB176742 PB179575
INTERPRO IPR003386

HMMER build information

Pfam_ls [download HMM] Pfam_fs [download HMM]
Gathering cutoff -116.60 -116.60 14.50 14.50
Trusted cutoff -114.30 -114.30 14.50 14.50
Noise cutoff -119.50 -119.50 14.20 14.20
Build method of HMM hmmbuild -F HMM_ls SEED
hmmcalibrate --seed 0 HMM_ls
 hmmbuild -f -F HMM_fs SEED
hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entryMian N, Bateman A
Type definitionFamily
Source of seed membersPfam-B_2099 (release 5.4)