Pfam 22.0 :: Cadherin_pro
Description of the Cadherin_pro family
Cadherin_C <-- --> Caenor_Her-1

Cadherin_pro


Accession number: PF08758
Cadherin prodomain like

Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions [1].

Description


Description text from InterPro entry IPR014868

Sequence information


Alignment

Seed (55)  Full (86)
Format:

Visualize domain structures

Seed (55)  Full (86)
display per page.

Species distribution

Tree depth:

Literature References

[1]
Structure of the neural (N-) cadherin prodomain reveals a cadherin extracellular domain-like fold without adhesive characteristics.
Koch AW, Farooq A, Shan W, Zeng L, Colman DR, Zhou MM;
Structure. 2004;12:793-805.

Database References

SCOP 1op4 (family)
INTERPRO IPR014868

HMMER build information

Pfam_ls [download HMM] Pfam_fs [download HMM]
Gathering cutoff -0.90 -0.90 17.30 17.30
Trusted cutoff 2.20 2.20 17.30 17.30
Noise cutoff -4.00 -4.00 16.90 16.90
Build method of HMM hmmbuild -F HMM_ls SEED
hmmcalibrate --seed 0 HMM_ls
 hmmbuild -f -F HMM_fs SEED
hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entryMistry J
Type definitionDomain
Source of seed memberspdb_1op4