Pfam 22.0 :: C2-set
Description of the C2-set family
C2 <-- --> C2-set_2

C2-set


Accession number: PF05790
Immunoglobulin C2-set domain

Description

This entry occurs in several mammalian T-cell surface antigen CD2 proteins as well as homologous African swine fever virus (ASFV) sequences. CD2 mediates T cell adhesion via its ectodomain and signal transduction utilising its 117-amino acid cytoplasmic tail PUBMED:11376005. The structural and functional similarities of the ASFV LMW8-DR to CD2, a protein that is involved in cell-cell adhesion and immune response modulation, suggest a possible role in the pathogenesis of ASFV infection PUBMED:7907198.
Description text from InterPro entry IPR008424

Sequence information


Alignment

Seed (27)  Full (131)
Format:

Visualize domain structures

Seed (27)  Full (131)
display per page.

Species distribution

Tree depth:

Database References

INTERPRO IPR008424

HMMER build information

Pfam_ls [download HMM] Pfam_fs [download HMM]
Gathering cutoff 25.00 25.00 25.00 25.00
Trusted cutoff 31.20 31.20 27.50 29.40
Noise cutoff 23.00 23.00 23.60 21.20
Build method of HMM hmmbuild -F HMM_ls SEED
hmmcalibrate --seed 0 HMM_ls
 hmmbuild -f -F HMM_fs SEED
hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entryBateman A, Finn RD, Moxon SJ
Type definitionDomain
Source of seed membersBateman A