AAA

AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].

A large family of ATPases has been described PUBMED:1860879, PUBMED:1825027, PUBMED:2140770, PUBMED:8507683, PUBMED:7646486 whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. This family is now called AAA, for 'A'TPases 'A'ssociated with diverse cellular 'A'ctivities. The proteins that belong to this family either contain one or two AAA domains.

It is proposed that, in general, the AAA domains in these proteins act as ATP-dependent protein clamps PUBMED:7646486.

In addition to the ATP-binding 'A' and 'B' motifs (see the relevant entry ), which are located in the N-terminal half of this domain, there is a highly conserved region located in the central part of the domain.

Alignment

Visualize domain structures

Species distribution