Pfam 22.0 :: Tap-RNA

Pfam 22.0 :: Tap-RNA_bind
Description of the Tap-RNA_bind family

Tannase <--	--> Tape_meas_lam_C
Tap-RNA_bind

Accession number: PF09162
Tap, RNA-binding

Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element [1].

Description

Description text from InterPro entry IPR015245

Sequence information

Alignment

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Species distribution

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Literature References

[1]
The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor.
Ho DN, Coburn GA, Kang Y, Cullen BR, Georgiadis MM;
Proc Natl Acad Sci U S A. 2002;99:1888-1893.

Database References

SCOP	1koh (family)
INTERPRO	IPR015245

HMMER build information

	Pfam_ls [download HMM]	Pfam_fs [download HMM]
Gathering cutoff	25.00 25.00	25.00 25.00
Trusted cutoff	43.40 43.40	42.10 42.10
Noise cutoff	-13.00 -13.00	16.20 15.20
Build method of HMM	hmmbuild -F HMM_ls SEED hmmcalibrate --seed 0 HMM_ls	hmmbuild -f -F HMM_fs SEED hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entry	Sammut SJ
Type definition	Domain
Source of seed members	pdb_1koh