Pfam 22.0 :: Xol-1

Pfam 22.0 :: Xol-1_N
Description of the Xol-1_N family

Xol-1_GHMP-like <--	--> Xpo1
Xol-1_N

Accession number: PF09108
Switch protein XOL-1, N-terminal

Members of this family, which are required for the formation of the active site of the sex-determining protein Xol-1, adopt a secondary structure consisting of five alpha helices and six antiparallel beta sheets, in a beta-alpha-beta-beta-beta-alpha-beta-alpha-alpha-alpha-beta arrangement. The fold of this family is similar to that found in ribosomal protein S5 domain 2-like [1].

Description

Description text from InterPro entry IPR015192

Sequence information

Alignment

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Species distribution

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Literature References

[1]
XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators.
Luz JG, Hassig CA, Pickle C, Godzik A, Meyer BJ, Wilson IA;
Genes Dev. 2003;17:977-990.

Database References

SCOP	1mg7 (family)
INTERPRO	IPR015192

HMMER build information

	Pfam_ls [download HMM]	Pfam_fs [download HMM]
Gathering cutoff	25.00 25.00	25.00 25.00
Trusted cutoff	354.00 354.00	352.20 352.20
Noise cutoff	-41.40 -41.40	10.30 10.30
Build method of HMM	hmmbuild -F HMM_ls SEED hmmcalibrate --seed 0 HMM_ls	hmmbuild -f -F HMM_fs SEED hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entry	Sammut SJ
Type definition	Domain
Source of seed members	pdb_1mg7