Pfam 22.0 :: c-SKI_SMAD_bind
Description of the c-SKI_SMAD_bind family
bZIP_Maf <-- --> cIII

c-SKI_SMAD_bind


Accession number: PF08782
c-SKI Smad4 binding domain

c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins [1]. This domain binds to Smad4 [2]

Description


Description text from InterPro entry IPR014890

Sequence information


Alignment

Seed (9)  Full (60)
Format:

Visualize domain structures

Seed (9)  Full (60)
display per page.

Species distribution

Tree depth:

Literature References

[1]
c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements.
Suzuki H, Yagi K, Kondo M, Kato M, Miyazono K, Miyazawa K;
Oncogene. 2004;23:5068-5076.
[2]
Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling.
Wu JW, Krawitz AR, Chai J, Li W, Zhang F, Luo K, Shi Y;
Cell. 2002;111:357-367.

Database References

SCOP 1mr1 (family)
INTERPRO IPR014890

HMMER build information

Pfam_ls [download HMM] Pfam_fs [download HMM]
Gathering cutoff -3.30 -3.30 20.00 20.00
Trusted cutoff 13.50 13.50 78.30 78.30
Noise cutoff -20.20 -20.20 15.20 15.20
Build method of HMM hmmbuild -F HMM_ls SEED
hmmcalibrate --seed 0 HMM_ls
 hmmbuild -f -F HMM_fs SEED
hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entryMistry J
Type definitionDomain
Source of seed memberspdb_1mr1