Tagatose_6_P_K

Proteins in this family are tagatose 6 phosphate kinases.

Escherichia coli and other enteric bacteria contain two closely related D-tagatose 1,6-bisphosphate (TagBP)-specific aldolases involved in catabolism of galactitol (genes gatY gatZ) and of N-acetyl-galactosamine and D-galactosamine (genes kbaY, kbaZ, also called agaY, agaZ). The catalytic subunits GatY/KbaY alone are sufficient to show aldolase activity and contain most or all of the residues that have been identified as essential in substrate/product recognition and catalysis for class II aldolases PUBMED:11976750, PUBMED:8955298. However, these aldolases differ from other Class II aldolases (which are homodimeric enzymes) in that they require subunits GatZ/KbaZ for full activity and for good in vivo and in vitro stability. The Z subunits alone do not show any aldolase activity PUBMED:11976750. It should be noted that the previous suggestion of a tagatose 6P-kinase function for AgaZ PUBMED:8932697 and other members of this family turned out to be erroneous PUBMED:10931310, PUBMED:11976750.

Alignment

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Species distribution