Pfam 22.0 :: Hairy_orange
Description of the Hairy_orange family
Haemagg_act <-- --> HalX

Hairy_orange


Accession number: PF07527
Hairy Orange

The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and Enhancer of Split [1,2]. The Orange domain is proposed to mediate specific protein-protein interaction between Hairy and Scute[2].

Description

This domain confers specificity among members of the Hairy/E(SPL) family. HES-2 (hairy and enhancer of split 2) is a transcription factor, and the hairy protein is a pair-rule protein that regulates embryonic segmentation and adult bristle patterning. These proteins are transcriptional repressors of genes that require the BHLH protein for their transcription.
Description text from InterPro entry IPR003650

Sequence information


Alignment

Seed (43)  Full (295)
Format:

Visualize domain structures

Seed (43)  Full (295)
display per page.

Species distribution

Tree depth:

Literature References

[1]
Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split.
Kokubo H, Lun Y, Johnson RL;
Biochem Biophys Res Commun 1999;260:459-465.
[2]
Specificity for the hairy/enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression.
Dawson SR, Turner DL, Weintraub H, Parkhurst SM;
Mol Cell Biol 1995;15:6923-6931.

Database References

SMART ORANGE
INTERPRO IPR003650

HMMER build information

Pfam_ls [download HMM] Pfam_fs [download HMM]
Gathering cutoff 20.00 20.00 20.00 20.00
Trusted cutoff 21.70 21.70 20.00 20.00
Noise cutoff 18.10 18.10 19.90 19.90
Build method of HMM hmmbuild -F HMM_ls SEED
hmmcalibrate --seed 0 HMM_ls
 hmmbuild -f -F HMM_fs SEED
hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entryStudholme DJ
Type definitionDomain
Source of seed members[1]