Pfam 22.0 :: DAP10
Description of the DAP10 family
DAO <-- --> DAP_B

DAP10


Accession number: PF07213
DAP10 membrane protein

This family consists of several mammalian DAP10 membrane proteins. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells [1].

Description

This family consists of several mammalian DAP10 membrane proteins. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells PUBMED:12740576.


Description text from InterPro entry IPR009861

Sequence information


Alignment

Seed (2)  Full (9)
Format:

Visualize domain structures

Seed (2)  Full (9)
display per page.

Species distribution

Tree depth:

Literature References

[1]
NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.
Zompi S, Hamerman JA, Ogasawara K, Schweighoffer E, Tybulewicz VL, Di Santo JP, Lanier LL, Colucci F;
Nat Immunol 2003;4:565-572.

Database References

INTERPRO IPR009861

HMMER build information

Pfam_ls [download HMM] Pfam_fs [download HMM]
Gathering cutoff 25.00 25.00 25.00 25.00
Trusted cutoff 174.10 174.10 172.10 38.60
Noise cutoff 23.10 23.10 22.10 22.10
Build method of HMM hmmbuild -F HMM_ls SEED
hmmcalibrate --seed 0 HMM_ls
 hmmbuild -f -F HMM_fs SEED
hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entryMoxon SJ
Type definitionFamily
Source of seed membersPfam-B_16910 (release 10.0)