Pfam 22.0 :: Kdo
Description of the Kdo family
KdgT <-- --> KdpA

Kdo


Accession number: PF06293
Lipopolysaccharide kinase (Kdo/WaaP) family

These lipopolysaccharide kinases are related to protein kinases Pkinase. This family includes waaP (rfaP) gene product is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that WaaP is necessary for resistance to hydrophobic and polycationic antimicrobials in E. coli and that it is required for virulence in invasive strains of S. enterica [1].

Description

These lipopolysaccharide kinases are related to protein kinases . This family includes waaP (rfaP) gene product is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that WaaP is necessary for resistance to hydrophobic and polycationic antimicrobials in Escherichia coli and that it is required for virulence in invasive strains of S. enterica PUBMED:11069912.


Description text from InterPro entry IPR010440

Sequence information


Alignment

Seed (14)  Full (185)
Format:

Visualize domain structures

Seed (14)  Full (185)
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Species distribution

Tree depth:

Literature References

[1]
Purification and characterization of WaaP from Escherichia coli, a lipopolysaccharide kinase essential for outer membrane stability.
Yethon JA, Whitfield C;
J Biol Chem 2001;276:5498-5504.
[2]
Lipopolysaccharide phosphorylating enzymes encoded in the genomes of Gram-negative bacteria are related to the eukaryotic protein kinases.
Krupa A, Srinivasan N;
Protein Sci 2002;11:1580-1584.
[3]
A Haemophilus influenzae gene that encodes a membrane bound 3-deoxy-D-manno-octulosonic acid (Kdo) kinase. Possible involvement of kdo phosphorylation in bacterial virulence.
White KA, Lin S, Cotter RJ, Raetz CR;
J Biol Chem 1999;274:31391-31400.

Database References

PFAMB
The following Pfam-B families contain sequences that according to Prodom are members of this Pfam-A family.
PB085269 PB176501
INTERPRO IPR010440

HMMER build information

Pfam_ls [download HMM] Pfam_fs [download HMM]
Gathering cutoff -14.00 -14.00 30.00 30.00
Trusted cutoff -13.10 -13.10 31.70 31.70
Noise cutoff -15.00 -15.00 29.70 29.70
Build method of HMM hmmbuild -F HMM_ls SEED
hmmcalibrate --seed 0 HMM_ls
 hmmbuild -f -F HMM_fs SEED
hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entryStudholme DJ
Type definitionFamily
Source of seed membersKrupa A, Srinivasan N