Pfam 22.0 :: L6_membrane (KISTI)

Pfam 22.0 :: L6_membrane
Description of the L6_membrane family

L51_S25_CI-B8 <--	--> L71
L6_membrane

Accession number: PF05805
L6 membrane protein

This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family [1]. Several members of this family have been implicated in human cancer [2,3].

Description
This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family PUBMED:10975581. Several members of this family have been implicated in Homo sapiens cancer PUBMED:1565644, PUBMED:9479038.
Description text from InterPro entry IPR008661

Sequence information

Alignment

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Seed (8) Full (46)

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Species distribution

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Literature References

[1]
The L6 membrane proteins--a new four-transmembrane superfamily.
Wright MD, Ni J, Rudy GB;
Protein Sci 2000;9:1594-1600.

[2]
Cloning and expression of the tumor-associated antigen L6.
Marken JS, Schieven GL, Hellstrom I, Hellstrom KE, Aruffo A;
Proc Natl Acad Sci U S A 1992;89:3503-3507.

[3]
Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer.
Muller-Pillasch F, Wallrapp C, Lacher U, Friess H, Buchler M, Adler G, Gress TM;
Gene 1998;208:25-30.

Database References

INTERPRO

IPR008661

HMMER build information

	Pfam_ls [download HMM]	Pfam_fs [download HMM]
Gathering cutoff	25.00 25.00	25.00 25.00
Trusted cutoff	48.50 48.50	127.30 115.50
Noise cutoff	-96.80 -96.80	15.40 19.70
Build method of HMM	hmmbuild -F HMM_ls SEED hmmcalibrate --seed 0 HMM_ls	hmmbuild -f -F HMM_fs SEED hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entry	Moxon SJ
Type definition	Family
Source of seed members	Pfam-B_7771 (release 8.0)