Pfam 22.0 :: TACC
Description of the TACC family
T4_gp9_10 <-- --> TACI-CRD2

TACC


Accession number: PF05010
Transforming acidic coiled-coil-containing protein (TACC)

This family contains the proteins TACC 1, 2 and 3 the genes for which are found concentrated in the centrosomes of eukaryotic and may play a conserved role in organising centrosomal microtubules. The human TACC proteins have been linked to cancer and TACC2 has been identified as a possible tumour suppressor (AZU-1) [1]. The functional homologue (Alp7) in Schizosaccharomyces pombe has been shown to be required for organisation of bipolar spindles [2].

Description

This family contains the proteins TACC 1, 2 and 3, found concentrated in the centrosomes of eukaryotes which may play a conserved role in organising centrosomal microtubules. The human TACC proteins have been linked to cancer and TACC2 has been identified as a possible tumour suppressor (AZU-1) PUBMED:11121038.
Description text from InterPro entry IPR007707

Sequence information


Alignment

Seed (12)  Full (47)
Format:

Visualize domain structures

Seed (12)  Full (47)
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Species distribution

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Literature References

[1]
The TACC domain identifies a family of centrosomal proteins that can interact with microtubules.
Gergely F, Karlsson C, Still I, Cowell J, Kilmartin J, Raff JW;
Proc Natl Acad Sci U S A 2000;97:14352-14357.
[2]
Interdependency of fission yeast Alp14/TOG and coiled coil protein Alp7 in microtubule localization and bipolar spindle formation.
Sato M, Vardy L, Angel Garcia M, Koonrugsa N, Toda T;
Mol Biol Cell. 2004;15:1609-1622.

Database References

INTERPRO IPR007707

HMMER build information

Pfam_ls [download HMM] Pfam_fs [download HMM]
Gathering cutoff 25.00 25.00 17.70 17.70
Trusted cutoff 65.00 65.00 19.70 19.70
Noise cutoff -56.90 -56.90 16.50 15.70
Build method of HMM hmmbuild -F HMM_ls SEED
hmmcalibrate --seed 0 HMM_ls
 hmmbuild -f -F HMM_fs SEED
hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entryMoxon SJ
Type definitionFamily
Source of seed membersPfam-B_4807 (release 7.6)