Pfam 22.0 :: VanZ
Description of the VanZ family
VanY <-- --> VapD

VanZ


Accession number: PF04892
VanZ like family

This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases [1].

Description

This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases. VanZ confers low-level resistance to the glycopeptide antibiotic teicoplanin (Te). Analysis of cytoplasmic peptidoglycan precursors, accumulated in the presence of ramoplanin, showed that VanZ-mediated Te resistance does not involve incorporation of a substituent of D-alanine into the peptidoglycan precursors PUBMED:7867956.


Description text from InterPro entry IPR006976

Sequence information


Alignment

Seed (22)  Full (401)
Format:

Visualize domain structures

Seed (22)  Full (401)
display per page.

Species distribution

Tree depth:

Literature References

[1]
The vanZ gene of Tn1546 from Enterococcus faecium BM4147 confers resistance to teicoplanin.
Arthur M, Depardieu F, Molinas C, Reynolds P, Courvalin P;
Gene 1995;154:87-92.

Database References

PFAMB
The following Pfam-B families contain sequences that according to Prodom are members of this Pfam-A family.
PB038673 PB050396 PB108584 PB169118 PB169252 PB169852 PB180059 PB181699
INTERPRO IPR006976

HMMER build information

Pfam_ls [download HMM] Pfam_fs [download HMM]
Gathering cutoff 5.40 5.40 17.90 17.90
Trusted cutoff 5.40 5.40 17.90 17.90
Noise cutoff 5.00 5.00 17.60 17.60
Build method of HMM hmmbuild -F HMM_ls SEED
hmmcalibrate --seed 0 HMM_ls
 hmmbuild -f -F HMM_fs SEED
hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entryFinn RD
Type definitionFamily
Source of seed membersPfam-B_5529 (release 7.6)