Pfam 22.0 :: EAL
Description of the EAL family
E7 <-- --> EAP30

EAL


Accession number: PF00563
EAL domain

This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function [1]. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site [1].

Description

This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function PUBMED:11557134. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site. It often but not always occurs along with PAS and DUF9 domains that are also found in many signalling proteins.
Description text from InterPro entry IPR001633

Sequence information


Alignment

Seed (55)  Full (4124)
Format:

Visualize domain structures

Seed (55)  Full (4124)
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Species distribution

Tree depth:

Literature References

[1]
Novel domains of the prokaryotic two-component signal transduction systems.
Galperin MY, Nikolskaya AN, Koonin EV;
FEMS Microbiol Lett 2001;203:11-21.

Database References

PFAMB
The following Pfam-B families contain sequences that according to Prodom are members of this Pfam-A family.
PB014201 PB016316 PB047713 PB063496 PB124504 PB182207
INTERPRO IPR001633

HMMER build information

Pfam_ls [download HMM] Pfam_fs [download HMM]
Gathering cutoff -110.30 -110.30 15.00 15.00
Trusted cutoff -110.00 -110.00 15.00 15.00
Noise cutoff -110.40 -110.40 14.80 14.90
Build method of HMM hmmbuild -F HMM_ls SEED
hmmcalibrate --seed 0 HMM_ls
 hmmbuild -f -F HMM_fs SEED
hmmcalibrate --seed 0 HMM_fs

Pfam specific information

Author of entrySMART
Type definitionFamily
Source of seed membersAlignment kindly provided by SMART